Anti-migraine drug. Specific and selective agonist of 5-HT1-serotonin receptors, localized predominantly in the blood vessels of the brain and it does not affect other subtypes of 5-HT-serotonin receptors (5-HT2-7). Causes narrowing of the vessels of the carotid arterial bed, that supply extracranial and intracranial tissues with blood (vasodilation of the meninges and / or their edema is the main mechanism of migraine development in humans) without significantly affecting cerebral blood flow.
Fights diarrhea (acute and chronic of various genesis: allergic, emotional, drug, radiation, with a change in diet and quality of food, in violation of metabolism and absorption), used for regulation of stool in patients with ileostomy. Loperamide (the effective ingredient of Imodium) reduces the tone and motility of the smooth muscles of the intestine. Slows down the peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes retention of fecal masses and reduced urge to defecate. The effect develops quickly and lasts for 4-6 hours.
Thiol derivative, a competitive hypoxanthine antagonist, has an immunosuppressive and cytostatic effect. It is used for prevention of rejection reaction in kidney transplantation, treatment of rheumatoid arthritis, chronic active hepatitis, SLE, dermatomyositis, periarteritis nodosa, acquired hemolytic anemia, gangrenous pyoderma, psoriasis, Crohn's disease, ulcerative colitis and myopathy.
NSAIDs; has an anti-inflammatory, analgesic and antipyretic effect associated with the suppression of COX1 and COX2 that regulate the synthesis of Pg. Used to inhibit miosis during surgery of cataracts in the treatment of inflammatory processes caused by surgery. It is also used in the prevention and treatment of cystoid edema of macular retina after surgical removal of cataracts.
BCCC; a derivative of diphenylalkylamine. Has antianginal, anti-arrhythmic and hypotensive effect. The antianginal effect is associated with both direct action on the myocardium and with the effect on peripheral hemodynamics. It is prescribed with stenocardia, supraventricular tachycardia, sinus tachycardia, ciliary tachyarrhythmia, atrial flutter, atrial extrasystole, arterial hypertension, GOKMP, primary hypertension in the "small" circle of the circulation.