Thiol derivative, a competitive hypoxanthine antagonist, has an immunosuppressive and cytostatic effect. It is used for prevention of rejection reaction in kidney transplantation, treatment of rheumatoid arthritis, chronic active hepatitis, SLE, dermatomyositis, periarteritis nodosa, acquired hemolytic anemia, gangrenous pyoderma, psoriasis, Crohn's disease, ulcerative colitis and myopathy.
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Imuran Product Description
Imuran is an immunosuppressive agent used for the suppression of immune responses in the treatment of autoimmune diseases or after organ transplantation. Imuran tablets can be used alone, or as a part of combined immunomodulatory therapy.
As an immunosuppressive antimetabolite, Imuran is approved as:
- Prevention of rejection of transplanted organs and improved survival after organ transplantation (including for medical management of renal, cardiac and hepatic transplant recipients).
- Management of active, severe, inflammatory and chronic autoimmune diseases of joints, skin, skeletal muscles, blood cells, arteries, liver and other organs and body systems.
Imuran maintenance dose to prevent transplant rejection ranges from 1mg to 4mg (once a day). The maintenance daily doses of Imuran for patients with autoimmune diseases vary from 1mg to 3mg (as a single or two divided doses).
If you take Imuran several times a day and skip a regular dose, take it as soon as you remember. Do not double Imuran dose and do not take extra immunosuppressive drugs to make up the missed dose.
To prevent transplant rejection, Imuran can be used together with other immunosuppressive agents. For symptomatic treatment of autoimmune diseases, Imuran can be used together with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs).
Imuran tablets should be protected from direct sunlight and stored in a dry place, at room temperature not exceeding 30°C.
Imuran Safety Information
Drugs suppressing immune responses (such as, Imuran) may increase the risk of developing malignancies. Patients with high risk of malignancies should be prescribed with Imuran only if the benefits of immunosuppressive therapy outweigh the potential risks.
Data about immunosuppressive therapy represented in this Imuran review is intended only for general information. This information in no case does not constitute an offer of a substitute for the immunologist’s professional medical advice or diagnosis of immune diseases. The online pharmacy shall not be held responsible for any damages resulting from the use of information about transplantation, autoimmune diseases and Imuran.
Imuran Side Effects
Imuran adverse reactions are reversible and disappear when decreasing the dose or duration of immunosuppressive therapy. The most severe adverse reactions of Imuran are hematologic and gastrointestinal disorders, such as leucopenia, infection, anemia, nausea, vomiting, hepatic toxicity, diarrhea, fever, malaise, vasculitis or muscle pain. Less often, Imuran may cause skin rashes, hair loss, fever, joint pain, steatorrhea, infections (e.g. viral, fungal and bacterial) or exanthem.