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Product description


Zebeta is a beta-1-selective adrenoblocker, which exerts an antihypertensive and anti-anginal action on the body. Bisoprolol fumarate, as an active ingredient, blocks beta-1-adrenergic receptors of the heart, thereby reducing the heart rate. Also, the drug reduces atrioventicular conductivity. The drug is able to block and beta-2-adrenergic receptors, but this is possible only at high doses. In this case, beta-2-adrenergic receptors are blocked primarily in the bronchi, as well as in the smooth muscles of the vessels.

Zebeta is used for arterial hypertension, ischemic heart disease (angina pectoris), and chronic heart failure.


Safety information


Bisoprolol is taken in a dosage of 5-10 mg once a day orally. The maximum daily dosage is 20 mg. A specific dosage is prescribed by the doctor individually, taking into account the heart rate and the effectiveness of treatment.

Zebeta may enhance the effects of other antihypertensive drugs.

In combination with reserpine, clonidine, guanfacin and alpha-methyldopa, a sharp decrease in heart rate is possible.

In combination with drugs foxglove, clonidine and guaafancine, there may be a disorder of the conduction of the heart.

In combination with calcium antagonists (dihydropyridone derivatives), the hypotensive effect of the drug may be enhanced.

Simultaneous administration of the drug Zebeta with veropomilom or diltiazem and other antiarrhythmic drugs, leads to lower blood pressure, reduces heart rate, develops an arrhythmia or heart failure.

In combination with derivatives of ergotamine, there may be an increase in the symptoms of peripheral circulatory disturbances.

In case of combination of Zebeta with insulin or oral hypoglycemic agents, the symptoms of glycemia are masked or mitigated.


Side effects


Fatigue, dizziness, headache, sleep disturbance, depression, rarely - hallucinations.

Contraindications:

  • Atrioventicular block of degree 2 and 3
  • Cariogenic shock
  • Syndrome of weakness of the sinus node
  • Bradycardia, sinoatrial block
  • Bronchial asthma
  • Arterial hypotension
  • Severe forms of peripheral circulation disorders
  • Psoriasis
  • Pregnancy
  • Simultaneous use of MAO inhibitors (with the exception of MAO type B inhibitors)
  • Breastfeeding period
  • Childhood
  • Hypersensitivity to the constituents of the preparation

The drug is prescribed with caution for patients with atrioventicular blockade of 1 degree, violation of peripheral blood circulation and cardiac activity, including with Raynaud's disease.

Same for patients with diabetes mellitus with significant fluctuations in the level of glycemia and metabolic acidosis.

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