Zestril is an angiotensin-converting enzyme inhibitor (ACE). It works by relaxing the blood vessels. This helps lower blood pressure. It is used in the treatment of high blood pressure, alone or in conjunction with other medicines.
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Zestril — is an antihypertensive medication from the ACE group used to treat retinopathy or diabetic nephropathy, heart failure and arterial hypertension. Zestril contains Lisinopril. Lisinopril is categorically contraindicated in people with a particular susceptibility to Lisinopril and other ingredients of this drug, in lactation, pregnancy, aortic stenosis and angioedema. Only specialist can prescribe dosage and the course of treatment.
— arterial hypertension (in monotherapy or in combination with other antihypertensive agents); - chronic heart failure (as part of combined therapy for the treatment of patients taking digitalis and / or diuretics);
— early treatment of acute myocardial infarction (within the first 24 hours with stable hemodynamic parameters in order to maintain these parameters and to prevent the left ventricular dysfunction and heart failure);
- Diabetic nephropathy (decrease in albuminuria in insulin-dependent patients with normal blood pressure and in insulin-independent patients with hypertension)
The drug is taken orally regardless of food intake regime. Patients with arterial hypertension who do not take other antihypertensives are prescribed 5 mg once a day. If there’s no effect, the dose is increased every 2-3 days by 5 mg to an average therapeutic dose of 20-40 mg / (increasing the dose above 40 mg usually does not lead to a further decrease in blood pressure). The usual daily maintenance dose is 20 mg. The maximum daily dose is 40 mg. The full effect usually develops in 2-4 weeks from the beginning of treatment, which should be taken into account when increasing the dose. It is possible to combine the drug with other antihypertensive drugs if clinical effect is insufficient.
— angioedema in anamnesis, also caused by use of ACE inhibitors;
— hereditary Quincke’s edema;
— age under 18 years (efficiency and safety are not determined);
— hypersensitivity to lisinopril or other ACE inhibitors;
– severe renal dysfunction, bilateral renal artery stenosis or arterial stenosis of a single kidney with progressive azotemia, a condition after kidney transplantation, renal failure, azotemia, hyperkalemia, aortic stenosis, hypertrophic obstructive cardiomyopathy, primary hyperaldosteronism, arterial hypotension, cerebrovascular diseases (including cerebral circulatory insufficiency),cardiac ischemia, coronary insufficiency, autoimmune systemic connective tissue diseases (including scleroderma, systemic lupus erythematosus); Oppression of bone marrow hematopoiesis; Diet with sodium restriction: hypovolemic conditions (including as a result of diarrhea, vomiting); elderly age.
Keep Zestril in a place inaccessible to children at a temperature of no higher than 30 ° C.
The most common side effects: dizziness, headache (in 5-6% of patients), weakness, diarrhea, dry cough, nausea, vomiting, orthostatic hypotension, skin rash, chest pain.
On the level of immune system: angioedema (face, lips, tongue, larynx or epiglottis, upper and lower extremities).
On the level of cardiovascular system: severe decrease in blood pressure, orthostatic hypotension, renal insufficiency, heart rhythm disturbances, palpitations.
On the level of central nervous system: increased fatigue, drowsiness, convulsive twitching of the muscles of the extremities and lips.
On the level of the hematopoiesis system the following side effects are possible: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, with long-term treatment - a slight decrease in the concentration of hemoglobin and hematocrit, erythrocytopenia.