Ampicillin - Semi-synthetic penicillin, which has a wide range of effects and exhibits bactericidal effect. Suppresses the synthesis of the cell wall of bacteria: Streptococcus pneumoniae, Staphylococcus spp., Bacillus anthracis, Clostridium spp., Enterococcus faecalis, Listeria spp., Haemophilus influenzae, Neisseria meningitidis, Proteus mirabilis, Pasteurella multocida, Salmonella spp., Shigella spp., Escherichia coli, Aerobic non-spore-forming bacteria. Acid-resistant.
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Ampicillin is a broad spectrum penicillin-like antibiotic of a semisynthetic group. It has a bactericidal effect by suppressing the synthesis of the bacterial cell wall. The drug does not degrade in the acidic environment of the stomach, it is well absorbed when ingested. It is active against gram-positive microorganisms, on which benzylpenicillin acts. In addition, it acts on a number of gram-negative microorganisms.
Indications for use
Ampicillin is used to treat patients with pneumonia, bronchopneumonia, with lung abscesses, sore throat, peritonitis, cholecystitis, sepsis, intestinal infections, postoperative soft tissue infections and other infections caused by sensitive microorganisms. The drug is highly effective for infections of the urinary tract caused by E. coli, proteus, enterococci or mixed infection, since it is excreted unchanged in urine in high concentrations. In large quantities, ampicillin also enters bile. The drug is effective in treating gonorrhea.
Mode of application
Before the appointment of this drug it is preferable to determine the sensitivity of the microflora to it, that caused the disease in this patient. Ampicillin is appoint inside, regardless of the intake of food. Single dose for adults is 0.5 g, daily - 2-3 g. Children are prescribed at the rate of 100 mg / kg. The daily dose is divided into 4-6 receptions.
The duration of treatment depends on the severity of the disease and the effectiveness of therapy.
The drug is contraindicated in cases of hypersensitivity to penicillin. When liver failure this drug is used under the control of liver function; in case of a bronchial asthma, a hay fever and other allergic diseases it is used only in case of an extreme necessity. At the same time prescribe desensitizing products.
Ampicillin enhances the effect of oral anticoagulants (drugs that are taken through the mouth to prevent blood clotting).
The drug should be administered with caution to patients with an indication of allergic reactions in the medical history.
There may be allergic reactions while ampicillin treatment in the form of skin rashes, urticaria, edema, Quincke, etc.
With prolonged ampicillin treatment weakened patients can possible develop superinfection - a severe, rapidly developing form of an infectious disease caused by drug-resistant microorganisms that didn't manifesting themselves previously in the body (yeast-like fungi, gram-negative microorganisms). It is expedient for these patients to simultaneously prescribe vitamins of group B and vitamin C, and if it is