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Zofran product description


Drug uses

Zofran is an antiemetic drug, intended for alleviating symptoms of gastrointestinal disorders in treatment of malignant tumors and neoplasms. The list of indications for Zofran use includes prevention, management and reduction of vomiting and nausea in children and adults:

  • after the use of chemotherapeutic agents and/or radiation therapy;
  • between the repeated cycles of cytotoxic therapy and radiotherapy.

Zofran reduces an incidence of nausea episodes and suppresses the vomiting reflex due to its influence on some central nervous system areas.

When selecting Zofran dose, the intensity, frequency and severity of gastrointestinal disorders should be taken into account. The maximum single dose of Zofran for antiemetic therapy in adults is 16mg. The maintenance Zofran dose for adults is 8 mg.

The duration of antiemetic Zofran therapy varies from 1 to 5 days. Zofran tablets are not recommended for long-term antiemetic therapy, lasting more than 5 days.


Missed dose

If you missed one or several Zofran doses, you should not double the next dose of the antiemetic. Antiemetic therapy can be stopped, if the vomiting reflex and nausea do not manifest after a missed dose of Zofran.


More information

The single Zofran dose can be increased to 24 mg for the symptomatic treatment of gastrointestinal side effects in highly emetogenic chemotherapy. Simultaneous use of Zofran with antibiotics, beta-blockers, anti-fungal or anti-arrhythmic agents increases the risk of arrhythmias.


Storage

Zofran tablets should be stored in the original container to protect from light. Store at room temperature, below 30°C.


Zofran safety information


Warnings

Zofran affects the serotonergic nervous system. Therefore, the patients may experience serotonin syndrome symptoms, when using Zofran in combination with other serotonergic drugs. Zofran tablets should be discontinued, if Zofran in combination with other CNS stimulants causes autonomic, gastrointestinal or psychiatric symptoms of serotonin syndrome.


Disclaimer

The information about antiemetic drug Zofran is not intended to be a substitute for professional medical care or pharmacy advice. The online pharmacy makes every effort to ensure the accuracy and timeliness of Zofran information update, but bears no responsibility for discrepancies, errors, or misinterpretation of any materials, presented for information purposes only.


Zofran side effects


Zofran tablets in the postoperative period:

  • may cause diarrhea in approximately 2% of children
  • may cause headaches in approximately 11% of adults

Side effect profiles in pediatric patients are comparable to those seen in adults, when antiemetic medicine Zofran is used to prevent chemotherapy-induced gastrointestinal reactions.

Less than 8% of children, adolescents and adults, using Zofran for the management of nausea and vomiting, caused by chemotherapeutic agents, may have headaches, diarrhea, and fever. Zofran tablets may cause constipation, flushing or feeling of warmth in some patients.

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