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Pain Relief
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Active ingredient: Tizanidine

Zanaflex (tizanidine) - the drug with an antispastic effect in increased muscle tone, relieves spasms and clonic convulsions.

Assign with painful muscular spasms associated with static and functional spine lesions (cervical and lumbar syndrome), and after surgery for a herniated disc or osteoarthritis of the thigh, as well as for spasms and pain due to multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord brain, stroke, with cramps of central origin.

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Tizanidine product description


Tizanidine is a relaxant of the central muscle that influences on the skeletal muscles. Tizanidine also has a balanced anodyne effect. This pharmaceutical product is used to cure chronic and acute spastic diseases of cerebral and spinal genesis. Tizanidine lessens clonic convulsions and spasms of the skeletal muscle which have occurred due to some neural pathologies such as retrogressive diseases of the spinal cord, multiple sclerosis, cerebral palsy, myelopathy of a chronic type, cerebrovascular accident, etc.), can lessen separate muscle spasms, as well as better the force of contractions of skeletal muscles of an arbitrary nature. It is assigned in cases of the functional and static ailment of the spine, such as radicular, cervical disorder, as well as during the post-surgery period (for example, after the aciurgy on osteoarthritis of the hip joint, spinal disc herniation).

Tizanidine hydrochloride (Zanaflex) lessens spasticity of muscles by blocking nerve impulses. However, this medical remedy does not lessen muscle tone. It acts for a short period of time and is effectively used when it is necessary to lessen spasticity symptoms for a while to complete recovery therapy after a stroke.


Tizanidine safety information


Among the contraindicated conditions, the specialists distinguish marked infraction of the hepatic functions; increased individual sensitivity to tizanidine or any other component of Zanaflex. The sedative products and alcohol potentiate the sedative effect of Tizanidine. Zanaflex is not recommended to be given to pregnant or lactating women, except for cases when the benefits of consuming the pharmaceutical exceed the possible risk of impact on the fetus or a newborn. It is strictly forbidden to combine fluvoxamine with tizanidine. Caution is necessary in the case of combining Zanaflex with other suppressors of CYP1 A2, for example, amiodarone, propafenone, mexiletine, cimetidine, pefloxacin, enoxacin, ciprofloxacin, norfloxacin, oral hormonal contraceptive products like rofecoxib and ticlopidine. In this case, dizziness, a decreased ability to psychomotor work may be experienced.


Tizanidine side effects


If you swallow Zanaflex tablets in low dosage to suppress the terrible muscle spasm, the adverse effects develop rarely, moreover, those are slightly expressed and transitory. The most common adverse effects which are likely to appear are low blood pressure, dry mouth, drowsiness, feeling dizzy. Less possible are nausea, digestive disturbances, enhanced activity of hepatic transaminases.

During simultaneous consumption of pharmaceutical products which reduce high blood pressure (and/or diuretics) and Tizanidine, the risk of bradycardia and arterial hypotension enhances. Consuming higher dosages of Zanaflex tablets (taking care of spasticity), a range of side effects may manifest more frequently and develop more often, which is not a signal to withdraw the administration of the tablets. Occasionally, the overdose may lead to problems like muscle weakness, insomnia, hallucinations.

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