Most indications for the use of such glucocorticoids as Medrol are due to their anti-inflammatory, immunosuppressive and anti-allergic properties. Due to these properties, the following therapeutic effects are achieved: reduction of the number of immune cells in the vicinity of inflammation; reduction of vasodilation; stabilization of lysosomal membranes; inhibition of phagocytosis; reduction of production of prostaglandins and related compounds.
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Synthetic glucocorticosteroid, which has anti-inflammatory, antiallergic and immunosuppressive activity. It has a strong effect on carbohydrate, protein and lipid metabolism. By activity is close to prednisolone, but almost does not have mineralocorticoid (sodium retardation) activity, which provides better tolerability. It is slowly absorbed when administered intramuscularly and has a longer lasting effect than hydrocortisone and prednisolone.
Indications and usage
Collagenoses, rheumatism, infectious nonspecific polyarthritis, bronchial asthma, acute lymphoblastic and myeloblastic leukemia, infectious mononucleosis, neurodermatitis, eczema and other skin diseases, various allergic diseases, Addison's disease, acute adrenocortical insufficiency, hemolytic anemia, glomerulonephritis, acute pancreatitis, shock and Collapse in surgical interventions;It is used to suppress the rejection reaction in the gomotransplantation of organs and tissues.
Mode of application
When bronchial asthma is prescribed by mouth, starting at 12-40 mg per day;Maintenance dose - 4-12 mg per day.When chronic polyarthritis (inflammation of several joints) is prescribed, starting from 6-20 mg per day.In rheumatoid arthritis they begin with Dr.eskers 0.8-1.5 mg / kg, then gradually diminish.
Depending on the disease, the daily dose averages 0.004-0.048 grams of methylprednisolone.The appointment of large doses may be required for multiple sclerosis (a systemic disease of the membranes of the nerve cells of the brain and spinal cord) - up to 0.2 g / day, brain edema - 0.2 g / day, organ transplants (transplantation) - up to 0,007 g/day.If the medicine has been used for a long time, its cancellation should be gradual.Doses are selected individually.With long-term treatment (to achieve the effect of the drug with a minimum of side effects), it is possible to take (in the mornings) a day after the dose equal to twice the daily dose.
Systemic fungal and other infections, hypersensitivity to the medicine, pregnancy, lactation, osteoporosis.
The delay of sodium and water in the body, loss of potassium, raising blood pressure, muscle weakness, osteoporosis (impaired bone supply, accompanied by an increase in its fragility), damage to the walls of the stomach, reducing the body's resistance to infection, mental disorders, suppression of adrenal function, menstrual cycle disorder.