It has a direct influence on muscles, mainly of arterial vessels over nitric receptor situated in blood vessels. Its active component is transformed into oxide in smooth muscles that effect prompts the activity of guanylate cyclases. It is crucial for the creation of cyclic guanosine monophosphate (relaxation mediator). The drug influence the processes in the central vascular system and heart activity. The nature and force of the influence of nitroglycerin on the cardiac organ and vessels depend on the cooperation of essential actions.
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These pills are aimed at expanding the vessel. It has an antianginal effect and its function is related to the fact that it releases nitric oxide active substances in the muscles of the vessels which are smooth.
Nitric oxide affects the activation of guanylate cyclase and makes the level of cyclic nucleotides higher as a result of it relaxes the smooth muscle. Under the influence of the drug, precapillary sphincters do not relax as well as large arteries and veins. This action is due to reflex reactions and the emergence of nitric oxide from the active substance in the walls of arterioles.
The effect of tablets due to the fact that the need for myocardium in oxygen will be less due to the fact that the load is reduced (peripheral veins expand and flow of the blood to the right atrium becomes less). The drug acts on the distribution of blood flow in subendocardial myocardial areas. It makes the highest tolerance to physical activity in people suffering from angina and if there is heart failure the tablets affect the unloading of the myocardium and reduce pressure in the small circle of blood circulation.
The cure is aimed at preventing attacks of angina. It is like the first aid for a person who has an acute myocardial infarction or insufficiency in the left ventricle. The cure is taken inside for the prevention of angina attacks. Tablets have restorative actions after myocardial infarction. The drug is taken intravenously in cases of acute myocardial infarction, left ventricular failure, unstable angina or pulmonary edema. It is used on the skin to prevent angina attacks.
The drug is prohibited for people who had a collapse of arterial hypotension, shock, myocardial infarction, which were accompanied by arterial hypotension. Do not take the drug if you have cardiac tamponade, toxic pulmonary edema, as well as high blood pressure including hemorrhagic stroke, after a recent head injury. It is forbidden for patients with high sensitivity to nitrates and high intraocular pressure.
It is necessary to take the cure on the skin or inside or intravenously. The dose of the drug is prescribed individually. It depends on the specific clinical situation and the dosage form that is used. Very carefully it is necessary to take the drug to people who have severe cerebral atherosclerosis, if blood circulation is impaired in the brain there is a tendency to anemia, for the elderly and for those who have obvious violations of the kidneys and liver.During pregnancy and lactation period the pills can be used only if the dose prescribed to the mother has no negative consequences for the development of the fetus or child.
People may observe the following negative effects on the body: head pain changes in skin sensation, heat. Sometimes they are dizzy and have hypotension. Sometimes if a person takes a large amount of medication, collapse and cyanosis may occur. Negative consequences such as nausea and vomiting arise from the digestive system. In the nervous system, the disorders like anxiety and psychotic reactions may occur. People may also have allergies that manifest in skin rashes and itching.